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When you're about to live the nicest day of your life you don't know it's gonna be the nicest. Until it doesn't become so. You don't recognize the nicest day of your life until you don't live it. The day in which you commit to something or someone. The day in which your heart breaks. The day in which you meet your soul mate, the day in which you realize that time isn't enough, because you'd want to live forever. Those are the nicest days, the perfect ones.

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Men are like high-heeled shoes... There are beautiful ones that are painful, those that you don't like from the start, those unattainable ones that'll never be yours, those that look charming at the beginning but then you understand that they aren't that special... and, lastly, those that you'll never tire to keep with you...

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At some point, you have to make a decision. Boundaries don't keep other people out. They fence you in. Life is messy. That's how we're made. So, you can waste your lives drawing lines. Or you can live your life crossing them. But there are some lines... that are way too dangerous to cross.
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The bad part of addiction is that is never ends well. Because at a certain point whatever made you good... stops being good... and starts to hurt you.
Yet they say that to get rid of the bad habit you must reach the limit. But how do you know when you've touched it?

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Okay, here it is, your choice... it's simple, her or me, and I'm sure she is really great. But Derek, I love you, in a really, really big pretend to like your taste in music, let you eat the last piece of cheesecake, hold a radio over my head outside your window, unfortunate way that makes me hate you, love you. So pick me, choose me, love me.

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- Dr. Meredith Grey: What was I to you? The girl you screwed to get over being screwed?
- Dr. Derek Shepherd: You were like coming up for fresh air. It's like I was drowning and you saved me. It's all I know.
- Dr. Meredith Grey: It's not good enough.

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You know how when you were a little kid and you believed in fairy tales, that fantasy of what your life would be, white dress, prince charming who would carry you away to a castle on a hill. You would lie in bed at night and close your eyes and you had complete and utter faith. Santa Claus, the Tooth Fairy, Prince Charming, they were so close you could taste them, but eventually you grow up, one day you open your eyes and the fairy tale disappears. Most people turn to the things and people they can trust. But the thing is its hard to let go of that fairy tale entirely cause almost everyone has that smallest bit of hope, of faith, that one day they will open their eyes and it will come true.
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Four hundred years ago, another well-known English guy had an opinion about being alone. John Donne. He thought we were never alone. Of course, it was fancier when he said it. "No man is an island entire unto himself." Boil down that island talk, and he just meant that all anyone needs is someone to step in and let us know we're not alone. And who's to say that someone can't have four legs. Someone to play with or run around with, or just hang out.

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When you were a kid, it was Halloween candy. You hid it from your parents and you ate it until you got sick. In college, it was the heavy combo of youth, tequila and well, you know. As a surgeon, you take as much of the good as you can get because it doesn't come around nearly as often as it should. 'Cause good things aren't always what they seem. Too much of anything, even love, is not always a good thing.

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Maybe we're not supposed to be happy. Maybe gratitude has nothing to do with joy. Maybe being grateful means recognizing what you have for what it is. Appreciating small victories. Admiring the struggle it takes to simply be human. Maybe, we're thankful for the familiar things we know. And maybe we're thankful for the things we'll never know. At the end of the day, the fact that we have the courage to still be standing is reason enough to celebrate.