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The only person that can keep a promise so big is God, and I haven't seen him pick up a scalpel lately.
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I get angry when I go without sleep.
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If I miss a real procedure because of this case, they're gonna call me 007 because I killed you.
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- Dr. Derek Shepherd: It's not the chase.
- Dr. Meredith Grey: What?
- Dr. Derek Shepherd: You and me. It is not the thrill of the chase. It's not a game. It's... it's your tiny ineffectual fists. And your hair.
- Dr. Meredith Grey: My hair?
- Dr. Derek Shepherd: It smells good. And you're very, very ballsy. It keeps me in line.
- Dr. Meredith Grey: I'm still not going out with you.
- Dr. Derek Shepherd: You say that now...

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- Dr. Derek Shepherd: So, who's next, Alex? He likes to sleep around... you two have that in common.
- Dr. Meredith Grey: You don't get to call me a whore! When I met you, I thought I had met the person I would spend then rest of my life with. I was done. So all the boys, and all the bars, and all the obvious daddy issues... who cared? Because I was done. You left me! You chose Addison! I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore!

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- Dr. Isobel "Izzie" Stevens: [to Alex] You wanna see it? You really wanna see it? Fine! Let's look at that tattoo up close and personal, shall we?
[she rips off her shirt]
- Dr. Isobel "Izzie" Stevens: What are these? Oh, my God! Breasts! How does anybody practice medicine hauling these things around? And what have we got back here? Lets see if I remember my anatomy.
[takes off her pants]
- Dr. Isobel "Izzie" Stevens: Gluts, right? Lets study them, shall we? Gather around and check out the booty that put Izzie Stevens through Med. School! You wanna call me Dr. Model? That's fine. But just remember that while you're all still sitting on 200 grand of student loans, I'm out of debt.
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- Dr. Christina Yang: You are eight feet tall. Your boobs are perfect. Your hair is down to there. If I was you I would just walk around naked all the time. I wouldn't have a job, I wouldn't have any skills, I wouldn't even know how to read. I would just be... naked.
- Dr. Isobel "Izzie" Stevens: It's makeup. It's retouching.
- Dr. Christina Yang: You get that we hate you, right?

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[to Meredith]
- Dr. Christina Yang: Burke wants to have a relationship... Boys are stupid.
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- Dr. Christina Yang: [About inviting Burke to Thanksgiving dinner] What was I supposed to do? Blow off my boyfriend for Thanksgiving?
[Pause]
- Dr. Christina Yang: I tried to. He wouldn't blow. He's like something sticky that won't blow off.

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- Dr. Derek Shepherd: I am not mentally challenged.
- Dr. Miranda Bailey: I'm not so sure about that.